Objective: Crohn’s disease is a chronic inflammatory gastrointestinal condition characterized by periods of relapse and remission. The incidence and prevalence of Crohn’s disease (CD) are increasing both globally and locally. This study aims to contribute to the literature by providing a retrospective analysis of patients diagnosed with CD in our hospital, thereby enhancing the Turkish data on the rising incidence of this condition.

Methods: This study included 247 patients diagnosed with Crohn’s disease (CD) who were at least 18 years old. These patients were monitored by the Department of Gastroenterology at Eskişehir Osmangazi University. The study covered the period from January 1, 2016, to September 1, 2020. Data were collected across various categories, including clinical, laboratory, radiological, and histological characteristics at the time of presentation, as well as disease-related complications.

Results: The mean age at diagnosis was 38.84 years, with a mean disease duration of 76.56 months. Terminal ileal involvement was observed in 40.9% of cases, colonic involvement in 19%, and ileocolonic involvement in 32.4%. An inflammatory phenotype was identified in 80% of cases. Complications occurred in 30% of patients, and 23.5% underwent surgery.

Conclusion: In our study, isolated terminal ileum involvement was the most common presentation. The older age at diagnosis and longer disease duration in this patient group suggest an increased risk of complications due to diagnostic delays. These findings highlight the need for future research to identify factors contributing to such delays in diagnosis.