Crohn’s disease (CD) has several intestinal and extraintestinal manifestations and complications, including fistulas, arthritis, and abscesses. Pyogenic liver abscesses are rare among the general population and also in patients with Crohn’s disease. They are associated with high mortality when treatment is delayed. Although Fusobacterium bacteremia and thrombophlebitis are most commonly reported in head and neck infections, the abdominal form is also a well-defined entity due to gastrointestinal colonization. We describe a case of liver abscesses and hepatic vein septic thrombosis due to Fusobacterium nucleatum in an adult male patient with Crohn’s disease.